Created on Wednesday, 03 Jul 2019. Posted in Funding
HTA has decided to no longer fund feasibility projects in its researcher led workstream. This is due to the fact that they are often costed at 4 times the equivalent of a feasibility project going to RfPB, they're over engineered and its difficult to judge value for money as the size and effect of a main trial remain obscure.
Instead HTA would like to see full trials with robust internal pilots to evaluate key feasibility outcomes and will fund such projects through staged payments.
HTA will continue to fund feasibility studies though it's commissioned workstream where the work is deemed to be absolutely essential and isn't likely to be funded selsewhere.
Lastly if a clinical trial is submitted to HTA based on a feasibility study you need to ensure that along side feasibility there also needs to be a convincing efficacy signal otherwise its unlikely to be funded.
Created on Tuesday, 14 May 2019. Posted in Funding
A partnership of twelve funders including charities, UK Research and Innovation (UKRI) councils and the UK health and social care departments have established the UK Prevention Research Partnership aiming to develop, test and refine new, practical and cost-effective approaches to preventing non-communicable diseases.
The £25 million has been earmarked for eight projects tackling the bigger picture factors behind the prevention of non-communicable diseases (NCDs) - illnesses that can’t be passed from person to person - such as heart disease, obesity, poor mental health, cancer and diabetes. NCDs make up the vast majority of illnesses in the UK, accounting for an estimated 89 per cent of all deaths. These projects aim to deliver real changes that reduce the burden of these diseases on our health and social care systems and enable people to live longer, healthier lives.
The list of current award recipiants and the next call for proposals will be launched in autumn 2019.
All applications to EME must cite some evidence that the intervention could work, i.e. that there is “proof of concept”. How much prior evidence of potential efficacy is needed will vary with the size of the translational step, the scale of the proposed study and the nature of the intervention. This document looks a examples of proof of concept that are accepted by the EME Funding Committees
There has been a question about the amount by which applications may vary in cost between Stage 1 and Stage 2 and a perception that costs should not vary by more than 10%. The official position is now that “It is accepted that a variance in costs is likely to occur between Stage 1 and Stage 2, but costs at each stage should represent value for money. Advisory committees may provide project specific costing guidance/feedback following stage 1.”
Created on Thursday, 04 Apr 2019. Posted in Funding
Every year innovators in England develop countless promising medical technologies, many of which are funded by the NIHR. But too many don’t make it all the way into the NHS and across the finish line of patient benefit.
In order to be of interest to the NHS, a product must address an existing clinical problem. It should be measured against the right comparators, and demonstrate either better patient outcomes, or cost savings, or both. In addition, its implementation needs to be sustainable; furthermore, there is a need to identify the clinical pathway that will be disrupted with its use, and the consequences of that disruption.
These questions are particularly difficult for SMEs to answer, as this requires novel trial approaches and a multidisciplinary effort, involving not only technology developers, but also clinicians, methodologists, health economists, implementation scientists, amongst others. These interventions can be expensive, and financial and time constraints sometimes limit their scope.
To help overcome this hurdle i4i is dedictaing its i4i Challenge Awards to real world implementation of mearket ready medtechinnovations.
Created on Wednesday, 27 Mar 2019. Posted in Funding
The NIHR has launched a new funding competition to allocate up to £56 million of funding over 5 years to public health research. The competition will award funding from the Department of Health and Social Care to 14 NIHR Health Protection Research Units (HPRUs) - partnerships between academic institutions and Public Health England (PHE). These new units will act as centres of excellence in multidisciplinary health protection research in England.
The NIHR have launched a new funding and awards database covering all of their funding streams, listing current and past projects.
Information on each award covers plain English summary and abstract, as well as the funding amount, investigators, start and end date, funding stream, research type and contracting organisation.
Created on Monday, 18 Mar 2019. Posted in Funding
There is often a mismatch between research activity and the burden of disease which needs to be addressed. The new NIHR theme promoting research activity following patient need hope to tackle this.
Recruiting in needs areas makes sense for a number of reasons
Commissioned briefs from NIHR will now contain hints where they would like researchers to include research naive areas within their study. Maps will be provided indicating disease burden alongside current recruitment to allow researchers to identify where they might engage with new partners.
Created on Monday, 11 Feb 2019. Posted in Funding
In Hywel Williams, HTA director's message this month he addresses the calls for clearer, informative feedback from the panel.
He pleges to make a concerted effort to provide better feedback especially to declined applications and to ensure that these are clearly written. Guidance has been given to panel members drafting feedback letter covering the 'would you understand it' and would it be helpful to you' points.
However it must be noted that applications often fail to convince the funding committee enough in many areas, but due to time constraints the panel will only communicate those areas where the application fell down. Challenges and rebuttles to the feedback can't be considered once the competitive funding panel has finished their deliberations.
Created on Monday, 04 Feb 2019. Posted in Funding
The Medical Research Council (MRC) and NIHR have launched a scheme offering full-time NHS consultants, who are research-qualified but not active, the opportunity to participate in high-quality, collaborative, research partnerships. The Clinical Academic Research Partnership (CARP) scheme will enable clinicians to contribute to research programmes as part-time co-investigators.