Research Design Service: East Midlands

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Core outcome set - response to COVID-19

  Created on Friday, 01 May 2020. Posted in Priorities | Methods

Many clinical trials and systematic reviews are already underway, or will begin shortly, to strengthen the evidence base for the COVID-19 response. Core outcome sets (COS), showing the outcomes that should be measured and reported in these studies, will ensure that this evidence base will contain, as a minimum, the key information needed by decision makers about the effects of interventions.

COMET core outcome sets for trials and systematic reviews


COVID-19 Research and Platform (Complex Innovative Design) Trials

  Created on Thursday, 30 Apr 2020. Posted in Methods

A Platform study allows for several experimental treatments to be studied simultaneously. In addition, new experimental treatments can be integrated into an existing study rather than setting up a new study. This allows for more efficient research

diagram of a platform study


Insights into adaptive studies and other complex and novel methods

  Created on Thursday, 30 Apr 2020. Posted in Methods

Research and Development Forum's slides from their Research but not as we know it: Managing novel methods in research symposium (March 2020)


Questionnaire design review service (QuestReviewTM)

  Created on Tuesday, 19 Mar 2019. Posted in Methods

Health Outcomes Insights offers a questionnaire design review service (QuestReviewTM) where they provide a detailed appraisal and report - based on best practice - on any weaknesses in the questionnaire’s design. This is an excellent service for researchers who want to design surveys but don’t have the experience.


The IDEAL Collaboration

  Created on Monday, 30 Jan 2017. Posted in Toolkit/Database | Methods

The IDEAL Collaboration is an initiative to improve the quality of research in surgery.

  • The model describes the stages of innovation in surgery: Idea, Development, Exploration, Assessment, Long-term study
  • There are a set of recommendations at each stage of the model that have been developed by experts in evidence-based surgery, for example on improving methodology and how to address the challenges of randomized controlled trials in surgery.
  • The IDEAL Framework describes the stages through which interventional therapy innovation normally passes, the characteristics of each stage and the study design types the collaboration recommends for each.

Important tip: recent HTA commissioned calls have mentioned this framework!


HS&DR 15/140/01 Challenges, solutions and future directions in the evaluation of service innovations in health care and public health (04:16)

  Created on Tuesday, 14 Jun 2016. Posted in Literature | Methods

This report is the output from a meeting in London in June 2015 that was funded by The Health Foundation, The Medical Research Council, the National Institute for Health Research and Universities UK. It brings together current approaches and methodologies for the evaluation of complex interventions in healthcare, and considers future challenges. The report covers 8 themes, including patient-reported outcome measures, healthcare equity, both qualitative and quantitative methods, and evidence synthesis.


Major funders collaborate to produce first in-depth guide on evaluating healthcare system innovations

  Created on Tuesday, 24 May 2016. Posted in Methods

Entitled Challenges, solutions and future directions in the evaluation of service innovations in health care and public health’, the book is the result of a partnership between the MRC, the National Institute for Health Research (NIHR) and the Health Foundation, together with Universities UK and Academy Health.

“This book will enable researchers, healthcare providers and policy makers to discover the most up-to-date methodologies for evaluation research, to prioritise these methods and implement them in the most appropriate manner to transform the provision of healthcare and public health.”


Stepped Wedge Randomized Controlled Trials – read the series now!

  Created on Monday, 21 Sep 2015. Posted in Literature | Methods

Guest edited by Professor David Torgerson this new series reviews previous stepped wedge studies, explores key issues of design and forms a comprehensive overview of the current state of knowledge of the design.

There is often a tension between policy makers wishing to implement a novel intervention and researchers wanting time to do a controlled evaluation.  One trial design that can address this tension is the stepped wedged randomised trial.  In a stepped wedge trial, all groups or clusters of participants eventually receive the intervention, but the implementation is staggered in a random fashion allowing a robust evaluation to take place.  Recently there has been an upsurge in interest in the design, which is not yet well understood.  This series of papers reviews previous stepped wedge studies and explores key issues of design, forming a comprehensive overview of the current state of knowledge of the design.